TL;DR: The closest YC-backed alternatives to <strong>Plena Health</strong> are other Y Combinator Healthcare companies, especially from the Spring 2026 batch. Below are 20 ranked competitors with batch, status, and team size.
Y Combinator-backed Healthcare companies similar to Plena Health (YC Spring 2026).
Last verified:
ClaraYC Spring 2026 · Active · 9 people— AI primary care doctor
FinalDoseYC Spring 2026 · Active · 5 people— Programmable DNA drug destroying all cancers, unlocking 80% of targets
KlarifyYC Spring 2026 · Active · 4 people— AI Agent for Therapists
AdialanteYC Spring 2026 · Active · 4 people— Cancer screening without barriers
LumiusYC Spring 2026 · Active · 4 people— Fast, smart, accessible 3D ultrasound that anyone can use
Arctic HealthYC Spring 2026 · Active · 4 people— AI-native credentialing and contracting for healthcare
VoquillYC Spring 2026 · Active · 3 people— The agentic OS for medical labs
JunoYC Spring 2026 · Active · 2 people— AI Health Assistant for Chronic Illness
HarborYC Spring 2026 · Active · 2 people— AI-native CRO for clinical trial operations
TaigaYC Spring 2026 · Active · 2 people— Autonomous medical billing
InferaYC Spring 2026 · Active · 2 people— Control lab instruments with natural language.
AbInitio BioYC Spring 2026 · Active · 2 people— The Intelligence layer for Drug Manufacturing
PanaceaYC Spring 2026 · Active · 2 people— AI-Native FDA Regulatory Services
Framewise HealthYC Spring 2026 · Active · 2 people— AI-native patient engagement
Lattice HealthYC Spring 2026 · Active · 1 people— Monitoring and governance for deployed medical imaging AI
BioStack PlatformsYC Spring 2026 · Active— Real world training envs for healthcare AI models
Ginkgo BioworksYC Summer 2014 · Public · 641 people— Our mission is to make biology easier to engineer.